Newtin applications require the .NET framework v1.1. To determine if you have it already, and how to get it, visit the Microsoft website's page What is .NET Framework. If you are running Vista, you must install .NET Framework 1.1 as well. .NET 1.1 will run in conjuction with .NET 2.x and 3.x.
Newtin Applications also require that the display settings be set to a minimum of 1024 x 768 and have a DPI setting of "Normal" (96dpi).